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Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.
TLDR
The radicicol-binding site appears to be specific to and is conserved in all members of the Hsp90 family of molecular chaperones from bacteria to mammals, but is not present in other molecular chapers with nucleotide-binding domains.
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.
TLDR
It is proposed that the AMAP1/cortactin complex, which is not detected in normal mammary epithelial cells, is an excellent drug target for cancer therapeutics.
Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol
TLDR
The present observations suggest that the anti-transformation effects of radicicol may be mediated, at least in part, by the association of Radicicol with HSP90 and the consequent dissociation of the Raf/HSP90 complex leading to the attenuation of the Ras/MAP kinase signal transduction pathway.
Biochemical and pharmacological studies with KT7692 and LY294002 on the role of phosphatidylinositol 3-kinase in FcεRI-mediated signal transduction
TLDR
A unique derivative of wortmannin is synthesized that has an inhibitory potency against PI3-kinase one-hundredth that of wortsmannin, but retains a similar potency to wortsin against MLCK.
Revised Structure and Stereochemistry of Hypothemycin
A cytotoxic 14-membered resorcylic macrolide, isolated from Coriolus versicolor (L. : FR.) QUEL., was found to be identical with hypothemycin, previously isolated from Hypomyces trichothecoides
Russuphelin A, a new cytotoxic substance from the mushroom Russula subnigricans Hongo.
A new cytotoxic substance, designated russuphelin A (1), has been isolated from the mushroom Russula subnigricans Hongo (Basidiomycetes). The structure was elucidated as
Biochemical and pharmacological studies with KT7692 and LY294002 on the role of phosphatidylinositol 3-kinase in Fc epsilon RI-mediated signal transduction.
TLDR
A unique derivative of wortmannin is synthesized that has an inhibitory potency against PI3-kinase one-hundredth that of wortsmannin, but retains a similar potency to wortsin against MLCK.
UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species.
TLDR
UCS1025A and B, novel pentacyclic polyketides with an unprecedented furopyrrolizidine skeleton, showed unique chemical equilibria involving three tautomeric isomers and exhibited antimicrobial activity and antiproliferative activity against human tumor cell lines.
EI-1511-3, -5 and EI-1625-2, novel interleukin-1 beta converting enzyme inhibitors produced by Streptomyces sp. E-1511 and E-1625. II. Structure determination.
TLDR
The structures of three novel interleukin-1 beta converting enzyme inhibitors were determined by spectroscopic methods and analyses of the CD spectra of the inhibitors and their oxidation products with chromium trioxide.
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