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Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol.
TLDR
Total synthesis of the anticancer 1,4-dioxane containing natural products silvestrol and episilvestrol is described by an approach based on the proposed biosynthesis of these novel compounds to find that the stereochemistry of the core was critical for activity. Expand