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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus.
BACKGROUND Hepatitis C virus (HCV) is the major etiological agent of hepatocellular carcinoma, and HCV RNA-dependent RNA polymerase (RdRp) is one of the main potential targets for anti-HCV agents.Expand
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The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals a Trypsin-like Fold and a Structural Zinc Binding Site
During replication of hepatitis C virus (HCV), the final steps of polyprotein processing are performed by a viral proteinase located in the N-terminal one-third of nonstructural protein 3. TheExpand
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The uniform rule with several commodities: A generalization of Sprumont’s characterization
Abstract This paper considers the problem of allocating multiple divisible commodities among a group of agents with single-peaked preferences. We show that the uniform rule is the only allocationExpand
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The essential role of C-terminal residues in regulating the activity of hepatitis C virus RNA-dependent RNA polymerase.
We have previously determined the crystal structure of a non-structural 5B (NS5B) protein, an RNA-dependent RNA polymerase (RdRp) of hepatitis C virus (HCV). NS5B protein with the hydrophobicExpand
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The conformation of hepatitis C virus NS3 proteinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor.
BACKGROUND Hepatitis C virus (HCV) NS3 proteinase activity is required for the release of HCV nonstructural proteins and is thus a potential antiviral target. The enzyme requires a protein cofactorExpand
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Equity and the Vickrey allocation rule on general preference domains
  • T. Adachi
  • Economics, Computer Science
  • Soc. Choice Welf.
  • 7 July 2014
We consider the problem of allocating multiple units of an indivisible good among a group of agents in which each agent demands at most one unit of the good and money payment or receipt is required. Expand
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Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors.
We report a new series of hepatitis C virus NS5B RNA polymerase inhibitors containing a conformationally constrained tetracyclic scaffold. SAR studies led to the identification ofExpand
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Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase
ABSTRACT JTK-853 is a novel piperazine derivative nonnucleoside inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase. JTK-853 showed potent inhibitory activity against genotype 1 HCVExpand
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Production and accumulation of xylooligosaccharides with long chains by growing culture and xylanase of a mutant strain of Bacillus pumilus X-6-19.
Bacillus pumilus X-6-9 isolated from soil and subsequently identified, produced xylooligosaccharides with long chains from xylan and accumulated them in the culture. By improving the cultureExpand
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Robust and secure implementation: equivalence theorems
  • T. Adachi
  • Computer Science
  • Games Econ. Behav.
  • 1 July 2014
This paper shows that in private value environments, strategy-proofness and the rectangular property are necessary conditions for (full) robust implementation (Bergemann and Morris, 2011). Expand
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