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Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.
Ghrelin possesses strong GH-releasing activity but also other endocrine activities including stimulation of PRL and ACTH secretion, modulation of insulin secretion and glucose metabolism. It isExpand
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Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity.
We investigated the metabolic actions of ghrelin in humans by examining the effects of acute administration of acylated ghrelin, unacylated ghrelin, and the combination in eight adult-onsetExpand
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Ontogeny of IGFs and IGFBPs mRNA levels and tissue concentrations in liver, kidney and skeletal muscle of pig.
As far as we know, there is no available information about ontogenic changes of tissue concentrations of IGF-I and II and IGFBPs in large mammals. Serum, liver and kidney levels of IGFs and IGFBPsExpand
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Des‐acyl ghrelin analogs prevent high‐fat‐diet‐induced dysregulation of glucose homeostasis
There is clinical evidence that des‐acyl ghrelin (DAG) favorably modulates glucose and lipid metabolism, although its mode of action is unknown. A murine model of prediabetes was used to assessExpand
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Insulin‐like growth factor‐l blood levels in severely burned patients: effects of time post injury, age of patient and severity of burn
OBJECTIVES Insulin‐like growth factor‐l (IGF‐I) is a polypeptide growth factor that stimulates protein synthesis. The aims of this study were to determine (1) the effect of a severe burn on bloodExpand
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Alterations of pituitary growth hormone-releasing factor binding sites in aging rats.
This study was designed to determine whether growth hormone (GH)-releasing factor (GRF) binding sites are altered in parallel to the diminution of GH secretion that occurs in aging. UsingExpand
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Prostaglandin E2 up‐regulates insulin‐like growth factor binding protein‐3 expression and synthesis in human articular chondrocytes by a c‐AMP‐independent pathway: Role of calcium and protein kinase
Insulin‐like growth factor‐1, IGF‐1, is believed to be an important anabolic modulator of cartilage metabolism and its bioactivity and bioavailability is regulated, in part, by IGF‐1 binding proteinExpand
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In vitro and in vivo stability and pharmacokinetic profile of unacylated ghrelin (UAG) analogues.
Ghrelin, an endocrine hormone predominantly produced by the stomach, exists in acylated and unacylated forms in the circulation. Unacylated ghrelin (UAG), the more abundant form in blood, possessesExpand
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Insulin-like growth factor-I concentration in Holstein female cattle: variations with age, stage of lactation and growth hormone-releasing factor administration.
Plasma insulin-like growth factor-I (IGF-I) concentrations were monitored in Holstein females through different periods of their growth, lactation and after acute or chronic growth hormone-releasingExpand
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IGF and IGF-binding protein system in the synovial fluid of osteoarthritic and rheumatoid arthritic patients.
Various arthritic disorders result from a disruption of the equilibrium between the synthesis and degradation of tissue matrix macromolecules. Growth factors, particularly insulin-like growthExpand
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