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Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice
Brain-derived neurotrophic factor (BDNF) is expressed at high levels in hippocampal neurons, and its expression is modulated by neural activity. Knockout mice can be used to study the roles ofExpand
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Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory
To explore the role of protein kinase A (PKA) in the late phase of long-term potentiation (L-LTP) and memory, we generated transgenic mice that express R(AB), an inhibitory form of the regulatoryExpand
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Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation
Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance both memory and synaptic plasticity. The current model for the action of HDAC inhibitors assumes that they alter geneExpand
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Requirement of a critical period of transcription for induction of a late phase of LTP.
Repeated high-frequency trains of stimuli induce long-term potentiation (LTP) in the CA1 region that persists for up to 8 hours in hippocampal slices and for days in intact animals. This long timeExpand
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Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA.
We have used a combined genetic and pharmacological approach to define the time course of the requirement for protein kinase A (PKA) and protein synthesis in long-term memory for contextual fearExpand
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Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss
Astrocytes modulate neuronal activity by releasing chemical transmitters via a process termed gliotransmission. The role of this process in the control of behavior is unknown. Since one outcome ofExpand
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Molecular mechanisms of memory acquisition, consolidation and retrieval
Memory is often considered to be a process that has several stages, including acquisition, consolidation and retrieval. Memory can be modified further through reconsolidation and performance canExpand
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Sleep deprivation impairs cAMP signaling in the hippocampus
Millions of people regularly obtain insufficient sleep. Given the effect of sleep deprivation on our lives, understanding the cellular and molecular pathways affected by sleep deprivation is clearlyExpand
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Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning.
Many behavioral and electrophysiological studies in animals and humans have suggested that sleep and circadian rhythms influence memory consolidation. In rodents, hippocampus-dependent memory may beExpand
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Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders.
Epigenetic chromatin remodeling and modifications of DNA represent central mechanisms for regulation of gene expression during brain development and in memory formation. Emerging evidence implicatesExpand
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