• Publications
  • Influence
The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance.
Recent genome-wide association studies demonstrated that common variants of solute carrier family 30 member 8 gene (SLC30A8) increase susceptibility to type 2 diabetes. SLC30A8 encodes zincExpand
  • 169
  • 15
  • Open Access
Mutations in prickle orthologs cause seizures in flies, mice, and humans.
Epilepsy is heritable, yet few causative gene mutations have been identified, and thus far no human epilepsy gene mutations have been found to produce seizures in invertebrates. Here we show thatExpand
  • 111
  • 5
Lymphotoxin Signal Promotes Thymic Organogenesis by Eliciting RANK Expression in the Embryonic Thymic Stroma
It has recently become clear that signals mediated by members of the TNFR superfamily, including lymphotoxin-β receptor (LTβR), receptor activator for NF-κB (RANK), and CD40, play essential roles inExpand
  • 85
  • 5
  • Open Access
The Mammalian DM Domain Transcription Factor Dmrta2 Is Required for Early Embryonic Development of the Cerebral Cortex
Development of the mammalian telencephalon is precisely organized by a combination of extracellular signaling events derived from signaling centers and transcription factor networks. Using geneExpand
  • 34
  • 5
Molecular mimicry between a uveitopathogenic site of S-antigen and viral peptides. Induction of experimental autoimmune uveitis in Lewis rats.
S-Antigen (S-Ag) is a well characterized 45,000 m.w. photoreceptor cell protein. When injected into susceptible animal species, including primates, it induces an experimental autoimmune uveitis, aExpand
  • 85
  • 1
Molecular mimicry between uveitopathogenic site of retinal S-antigen and Escherichia coli protein: induction of experimental autoimmune uveitis and lymphocyte cross-reaction.
Experimental autoimmune uveitis (EAU) is caused by the immunization of microgram amounts of a soluble retinal protein, known as S-antigen, in susceptible animal strains including primates. TheExpand
  • 44
  • 1
Studies of tolerance in schistosomiasis.
We have studied the induction of immune tolerance by exogenous exposure to schistosomal egg antigen (SEA). We compared routes of administration, exposure to different forms of SEA (eggs, normal SEA,Expand
  • 9
Cyclophosphamide-induced tolerance in fully allogeneic heart transplantation in mice.
We have established a long-lasting heart allograft tolerance in H-2-incompatible combinations by intravenous injection of 10(8) allogeneic spleen cells followed by the administration of 200 mg/kg ofExpand
  • 5
S-antigen: from gene to autoimmune uveitis.
Retinal S-antigen (S-Ag) is capable of inducing experimental autoimmune uveitis (EAU) in laboratory animals. EAU may serve as an animal model for studying human uveitis. As a first step we haveExpand
  • 38
Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1.
To conduct comprehensive characterization of molecular properties in organisms, we established an efficient method to produce knockout (KO)-rescue mice within a single generation. We applied thisExpand
  • 37
  • Open Access