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Effect of sex hormones on levels of mRNAs coding for proteins involved in lipid metabolism in macrophages
The effects of sex hormones estradiol (E2), testosterone (Te), and 5α-dihydrotestosterone (DT) on cholesterol accumulation induced by modified low density lipoproteins (LDL) in macrophagesExpand
Lipid Regulators during Atherogenesis: Expression of LXR, PPAR, and SREBP mRNA in the Human Aorta
Transcription factors LXRs, PPARs, and SREBPs have been implicated in a multitude of physiological and pathological processes including atherogenesis. However, little is known about the regulation ofExpand
Progestins and carcinogenesis
Progesterone and its analogs may exert opposite effects on cell proliferation, apoptosis, and epithelial–mesenchymal transition, leading to higher cell motility and metastasis. Their ultimate effectExpand
Changes of lysosomes in the earliest stages of the development of atherosclerosis
One of hypotheses of atherosclerosis is based on a presumption that the zones prone to the development of atherosclerosis contain lysosomes which are characterized by enzyme deficiency and thus, areExpand
Approaches to the design of selective ligands for membrane progesterone receptor alpha
A number of progesterone derivatives were assayed in terms of their affinity for recombinant human membrane progesterone receptor alpha (mPRα) in comparison with nuclear progesterone receptor (nPR).Expand
[Molecular basis and tissue specificity of the progestins action].
The review considers the effect of progestins on the function, proliferation, and apoptosis of cells of various organs in health and noncancerous disorders. Data are summarized to describe theExpand
Pregna-D′-pentarane structure influences progesterone receptor affinity for DNA
Electrophoretic mobility shift assay was used to determine whether pregna-D'-pentaranes allow progesterone receptor (PR) from rat uterine cytosol to bind hormone response element (HRE)-containingExpand
Changes in levels of gene expression in human aortal intima during atherogenesis
Changes in the contents of 36 mRNAs species related to lipid turnover, inflammation, metabolism and the action of sex hormones in samples of aortal intima along the “intact tissue — lesions of type IExpand
Contents of mRNAs encoding endosome/lysosome components in normal human aorta and in stage ii of atherogenesis: a hidden regulation
Contents of mRNAs encoding endosome/lysosome components EEA1, Rab5a, Lamp1, Lamp2, p62 (SQSTM1), and CD63 were measured by quantitative PCR and compared in intact fragments of human aorta and inExpand