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Journals and Conferences
A cell line derived from H35 hepatoma cells resistant to methotrexate (MTX) as a result of a defective transport system for MTX has been examined to determine how closely the variant resembles the parent cells with regard to other biochemical properties. The capacity of extracts of resistant cells to catalyze the poly-gamma-glutamylation of MTX was… (More)
Mice made phenylketonuric from birth until maturity by continuous administration of phenylalanine plus tyrosine had a subnormal maze-learning ability which was largely prevented when serotonin congeners such as melatonin or 5-hydroxytryptophan were administered continuously from birth to maturity. These results were interpreted to mean that the mental… (More)
Serotonin deficiency induced in newborn mice and maintained to adulthoodresulted in reduced ability to learn a maze. The serotonin deficiency was produced by overloading with phenylalanine plus tyrosine (to cause phenylketonuria), by feeding of reserpine, and by feeding of chlorpro mazine from birth to maturity.