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BACKGROUND AND PURPOSE Alzheimer disease (AD) is a neurodegenerative disease characterized by progressive dementia. The hippocampus is particularly vulnerable to damage at the very earliest stages of AD. This article seeks to evaluate critical AD-associated regional changes in the hippocampus using machine learning methods. MATERIALS AND METHODS(More)
BACKGROUND AND PURPOSE Normal-appearing brain tissue (NABT) damage was established in multiple sclerosis by histology, MR spectroscopy, magnetization transfer imaging and diffusion tensor imaging (DTI). However, whether this phenomenon can be detected in relapsing neuromyelitis optica (RNMO) remains unclear. The aim of this study was to use DTI to(More)
We present a computational method for operon prediction based on a comparative genomics approach. A group of consecutive genes is considered as a candidate operon if both their gene sequences and functions are conserved across several phylogenetically related genomes. In addition, various supporting data for operons are also collected through the(More)
Aneurysmal bone cyst (ABC) is an aggressive, pediatric bone tumor characterized by extensive destruction of the surrounding bone. Although first described over 60 years ago, its molecular etiology remains poorly understood. Recent work revealed that ABCs harbor translocation of TRE17/USP6, leading to its transcriptional upregulation. TRE17 encodes a(More)
AIMS The objective of the present study was to verify the correlation of chromosomes 1p and 19q status and expressions of O(6)-methylguanine DNA methyltransferase (MGMT), p53 and Ki-67 in diffuse gliomas of World Health Organization grades II and III. METHODS A series of 146 diffuse gliomas, including 45 oligodendrogliomas, 42 oligoastrocytomas and 59(More)
The aim of this study was to investigate the effects of transcranial direct current stimulation (TDCS) on hemichannel pannexin-1 (PX1) in cortical neurons and neural plasticity, and explore the optimal time window of TDCS therapy after stroke. Adult male Sprague-Dawley rats (n=90) were randomly assigned to sham operation, middle cerebral artery occlusion(More)
BACKGROUND Interactions between the thalamus and the cortex play an important role in consciousness. The thalamus as a homogenous structure is less strongly connected with the default mode network (DMN) in patients with disorders of consciousness (DOC), but the roles of specific thalamic nuclei are not clear. The purpose of this study was to investigate the(More)
BACKGROUND AND PURPOSE Most previous neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) rely on the manual delineation of the region of interest, which is subjective and lacks reproducibility. The purpose of this study was to use an automated method to assess whether there are abnormalities in the brains of patients with ADHD. In view(More)
BACKGROUND AND PURPOSE Many studies have reported abnormal changes in relapsing-remitting multiple sclerosis (RRMS) by histogram and region-of-interest-based methods by using diffusion tenor imaging. However, there are few studies on specific white matter fiber tracts of RRMS. Our study sought to use diffusion tensor tractography-based group mapping to(More)
This ultrastructural and light microscopic immunocytochemical study describes the time course of anatomical changes that occur in striatal astrocytes in response to neuronal deafferentation in young adult rats and the coordinate distribution of two astrocytic proteins involved in reactive synaptogenesis, glial fibrillary acidic protein and clusterin. We(More)