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The molecular events leading to the development and progression of ovarian carcinoma are not completely understood. We performed a large-scale survey for the identification of differentially expressed genes between ovarian carcinoma and normal ovarian tissue by using cDNA microarray analysis. We utilized 512 member human novel putative oncogene and tumor(More)
  • T Fu, G Liu
  • 1992
The protective effect of biphenyl dimethyl dicarboxylate (DDB) on chemically induced damages was studied in isolated suspended rat hepatocytes. The experimental results showed that DDB (200 micrograms/10(6) cells) efficiently protected the hepatocytes against carbon tetrachloride (CCl4 10 mmol.L-1) and D-galactosamine (1 mmol.L-1) induced damages. Membranal(More)
We first established a human ovarian sarcomatoid carcinoma cell line designated BUPH:OVSC from primary culture. The specimen was derived from the mural nodule in an ovarian mucinous tumor and cultured in vitro. To date, the cell line has been maintained for over 100 passages. Its biologic characteristics were studied by light and electron microscopy, which(More)
Ovarian carcinoma anti-idiotypic antibody 6B11 was murine derived; we previously have cloned 6B11 single-chain Fv antibody (6B11ScFv) and constructed the 6B11ScFv/human granulocyte-macrophage colony stimulating factor (GM-CSF) fusion protein (designated as 6B11GM) to enhance the immunogenecity of the single-chain Ab(2). Because of the difference in species(More)
In previous studies in our laboratory, heteroantisera were produced in rabbits by immunization with extracts of ascitic fluids from ovarian epithelial carcinomas. Reverse passive hemagglutination (RPHA) assay of these sera was used for the immunodiagnosis of ovarian cancer. Antibodies attached to lysed sheep red blood cells were able to detect tumor(More)
BACKGROUND AND AIMS Mutations in the disheveled, Egl-10 and pleckstrin domain-containing protein 5 (DEPDC5) gene have emerged as an important cause of various familial focal epilepsy syndromes. However, the significance of DEPDC5 mutations in patients with sporadic focal epilepsy has yet to be characterized. MATERIALS AND METHODS We studied a kindred of(More)
  • T Fu, J Lin
  • 2001
OBJECTIVE To study the effect of Cordyceps sinensis on inhibiting systemic lupus erythematosus (SLE) in MRL 1pr/1pr rats. METHODS The evalutions of lymphnoditis, proteinuria, kidney function and plasma antibody were adopted in MRL 1pr/1pr rats. RESULTS Cordyceps sinensis could inhibit lymphadenectasis, induce the level of proteinuria and anti-ds-DNA(More)
Forty-eight cases subjected to radioimmunoimaging (RII) by intraperitoneal injection with 131I-C0C183B2 monoclonal antibody (MAb) prepared in our laboratory were studied. Thirteen of 14 cases of proved primary ovarian carcinoma were positive. In 11 follow-up cases of ovarian carcinoma after initial surgery and chemotherapy, 5 recurrences were positive and 6(More)
Three murine monoclonal antibodies COCL66-9, COC183A5 and COC183B2 were raised against human epithelial ovarian adenocarcinoma with soluble antigens. The monoclonal antibodies were stable after culture and stored under 80 C for 9 to 20 months. The subclass and titre were all examined and the reactivities were tested on various paraffin embedded tissue(More)
A full-term baby boy with a segmental defect of the ileal musculature associated with terminal ileal and biliary atresia is presented. The newborn had a dilated loop of the ileum 30 cm proximal to the ileal atretic site. Pathological study results showed absence of the intestinal musculature with relatively intact mucosa. Foci of recent muscular necrosis(More)