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The above section makes it clear that even if an Na-Ca exchange exists in vascular smooth muscles, the clear involvement of Na ions in the generation of tension can in many cases be explained by the operation of mechanisms other than Na-Ca exchange. Readers who have got this far may still be unclear whether we believe that smooth muscle cells do possess the(More)
The present study was undertaken to examine Mn as a contractile agent in its own right in the absence of extracellular Ca and after the depletion of Ca from agonist-releasable stores. The results show that isolated strips of taenia coli depolarized by high-K, Ca-free solution will contract when Mn is present. Similarly, carbachol will evoke contractions in(More)
The effects of forskolin, an activator of adenylate cyclase, on the release of vasopressin from isolated rat neurointermediate lobes during a 10 min period of potassium stimulation were investigated. Forskolin was added 5 min after the onset of potassium stimulation. A concentration-dependent reduction in the amount of hormone released during the remaining(More)
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