T V Beregovaia

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In chronic experiment on dogs it has been established that the subcutaneous injection of equimolar doses of izadrine (nonselective beta-adrenergic agonist), alupent (moderately selective beta 2-adrenergic agonist) and salbutamol (predominantly beta 2-adrenergic agonist) suppresses the pentagastric secretion approximately in the same degree. The blockade of(More)
The preganglionic parasympathetic innervation of normal and vagotomized rat stomach have been investigated by the horseradish peroxidase (HRP) technique. After the HRP injection into the antrum and fundus muscles the labelled cells were revealed in nuclei dorsalis nervi vagi bilaterally, but preferentially in the left nucleus. The most numerous labelled(More)
Subcutaneous injection of serotonin (0.3 mg/kg) inhibited the carbocholine gastric secretion in dogs. The insulin secretion was suppressed only by the i.v. injection of serotonin. The latter decreased the blood flow in the stomach mucosa and intensified the motility of gastro-intestinal tract in hungry and replete dogs. The vagotomy and benzohexonium(More)
Peritol produces a marked inhibiting effect on the gastric secretory function in dogs with fistulas of the stomach and duodenum stimulated by insulin and carbacholin while the influence on the pentagastrin gastric secretion was weaker. In its effect on the histamine secretion peritol inhibits only the secreted juice pepsin. The practical importance of the(More)
The influence of vagotomy on histamine gastric secretion and the ability of the H2-blocker cimetidine to suppress histamine gastric secretion was examined in humans and dogs. It was established that vagotomy in humans decreased histamine acid secretion. The relative ability of cimetidine to suppress gastric secretion remained unchanged. In dogs, vagotomy(More)
The chronic experiments on dogs with fundal fistulas have revealed that the partial stomach denervation (selective proximal, selective distal and subcardial vagotomies) decreases the gastric secretory responses caused by submaximal and maximal doses of histamine. Selective and extragastral vagotomies do not change the histamine gastric secretion in dogs,(More)
In chronic experiments on dogs with the gastric fistulas it was shown that H1-histamine blockers (suprastin, peritol, pipolphen) fail to enhance histamine secretion and a selective H1-agonist IEM-813 fails to suppress it. It was also found that the ability of pipolphen to suppress the gastric secretion was due to its cholinolytic properties.