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Concurrent administration of 1alpha,25-dihydroxycholecalciferol [1alpha,25-(OH)2-CC] to intact and thyroparathyroidectomized rats treated with ethane-1-hydroxy-1,1-diphosphonate (EHDP) prevented or reversed the EHDP-induced inhibition of bone mineralization as measured by changes in epiphyseal plate width and ash content of bone. An analog,(More)
A single oral dose (150 mg/kg) of DL-6-(N-alpha-pipecolinomethyl)-5-hydroxy-indane maleate dissoved in distilled water was administered to Sprague-Dawley male rats living under controlled conditions. After dosage the male rats cohabited with female rats which were replaced weekly. The incidence of pregnancy was determined for 20 weeks. The male rats were(More)
Nine metabolites and analogs of cholecalciferol (CC) were tested for ability to increase tibia ash weight in chicks otherwise deprived of vitamin D. All of the compounds promoted bone mineralization in a linear log dose-response relationship. The maximal response obtained for any compound was an approximate doubling in bone ash weight compared to(More)
The effects of some androgenic-myotrophic steroids on pubertal ovulation in rats were studied. Treatment began at age 32 days. Steroids were given subcutaneously for 14 consecutive days. Autopsy was on the fifteenth day. The control animals showed an ovulation rate of 98% (137/140 rats). All of the steroids tested suppressed ovulation but differed in(More)