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1 Food and Drug Administration. Pradaxa (dabigatran etexilate mesylate): drug safety communication-safety review of post-market reports of serious bleeding events. http://www.fda.gov/Safety/MedWatch/ SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm 282820.htm. Accessed 10 March 2012. 2 Therapeutic Goods Administration, Australia. Dabigatran(More)
BACKGROUND The conjunctival flora is of great interest for each case of intraocular operation preventing postoperative infections. Despite of negative cultures before the operation we investigated in a prospective randomized study perioperatively the bacterial situation of the conjunctiva in 105 patients. MATERIAL AND METHODS We took conjunctival swabs(More)
Transmission of human cytomegalovirus (CMV) via transfusion (TT-CMV) may still occur and remains a challenge in the treatment of immunocompromised CMV-seronegative patients, e.g. after stem cell transplantation, and for low birthweight infants. Measures to reduce the risk of TT-CMV have been evaluated in clinical studies, including leucocyte depletion of(More)
BACKGROUND The THERAFLEX UV-Platelets pathogen reduction system for platelet concentrates (PCs) operates with ultraviolet C light (UVC; 254 nm) only without addition of photosensitizers. This phase I study evaluated safety and tolerability of autologous UVC-irradiated PCs in healthy volunteers. METHODS Eleven volunteers underwent two single (series 1 and(More)
BACKGROUND Platelet concentrates (PC) are transfused to improve primary haemostasis before urgent neurosurgery in patients with intracranial haemorrhage (ICH) receiving antiplatelet therapy (APT). It is unresolved, whether PCs increase the risk for major cardio- and cerebrovascular adverse events. We evaluated a standardized transfusion regimen to reverse(More)
Rebekah Stevenson: Characterization of Adolescent and Adult Ethanol Sensitization (Under the direction of Dr. Clyde Hodge) Alcoholism is a serious health problem that affects the lives of millions of people worldwide. People that first experiment with alcohol as adolescents are at a greater risk to become alcoholics. The adolescent brain may be particularly(More)
BACKGROUND A 100% apheresis platelet supply is considered to increase transfusion safety by lowering donor exposures for transfusion recipients. We performed a risk benefit analysis to contrast the reduction of donor exposures and the risk of contaminated blood products in the nation-wide inventory with the donor risks associated with a switch to a 100%(More)
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