T. Sullivan

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This work is concerned with establishing the feasibility of a data-on-demand (DoD) uncertainty quantification (UQ) protocol based on concentration-of-measure inequalities. Specific aims are to establish the feasibility of the protocol and its basic properties, including the tightness of the predictions afforded by the protocol. The assessment is based on an(More)
We consider the problem of providing optimal uncertainty quan-tification (UQ) — and hence rigorous certification — for partially-observed functions. We present a UQ framework within which the observations may be small or large in number, and need not carry information about the probability distribution of the system in operation. The UQ objectives are posed(More)
We present an optimal uncertainty quantification (OUQ) protocol for systems that are characterized by an existing physics-based model and for which only legacy data is available, i.e., no additional experimental testing of the system is possible. Specifically, the OUQ strategy developed in this work consists of using the legacy data to establish, in a(More)
Liver and lung metastases are the predominant cause of colorectal cancer (CRC)-related mortality. Recent research has indicated that CXCR3/chemokines interactions that orchestrate haematopoetic cell movement are implicated in the metastatic process of malignant tumours, including that of CRC cells to lymph nodes. To date, however, the contribution of CXCR3(More)
Architectural layouts of reinforced concrete buildings often require structural walls, with varying dimensions, to be placed in an asymmetric plan configuration. During seismic excitation the asymmetry induces a torsional component of response, which can impact negatively on the performance of the building by increasing demands on both structural and(More)
Containment systems for storage of solidified high-level radioactive wastes in bedded salt deposits " (1972). This dissertation was produced from a microfilm copy of the original document. While the most advanced technological means to photograph and reproduce this document have been used, the quality is heavily dependent upon the quality of the original(More)
In this brief, we presented a novel P-FF design by employing a modified TSPC latch structure incorporating a mixed design style consisting of a pass transistor and a pseudo-nMOS logic. The key idea was to provide a signal feedthrough from input source to the internal node of the latch, which would facilitate extra driving to shorten the transition time and(More)
This Part II of this series is concerned with establishing the feasibility of an extended data-on-demand (XDoD) uncertainty quantification (UQ) protocol based on concentration of measure inequalities and martingale theory. Specific aims are to establish the feasibility of the protocol and its basic properties, including the tightness of the predictions(More)