T Sturgeon

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BACKGROUND Increasing evidence suggests that an effective AIDS vaccine will need to elicit broadly neutralizing antibody responses. However, the mechanisms of antibody-mediated neutralization have not been defined. Previous studies from our lab have identified significant differences in the rates of antibody binding to trimeric SIV envelope proteins that(More)
Background The C-terminal tail (CTT) of HIV-1 envelope transmembrane protein has recently been the subject of an increasing number of studies to determine its role in the architecture of the HIV virion and in virus replication. Published studies from our lab have previously demonstrated that the lentivirus lytic peptides (LLP) domains contained in the CTT(More)
Background The HIV-1 envelope (Env) transmembrane protein, gp41, is typically considered a type I membrane protein with an extracellular N-terminus, a single membrane spanning domain, and a C-terminus forming a ~150 residue intracytoplasmic tail. However, published studies have indicated an alternative or dynamic topology for portions of the C-terminal tail(More)
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