T Stoytchev

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Neuropharmacological screening of five 1-alkyl derivatives of 3,3-diethyl-2,4-pyridinedione was performed on male albino mice. The substances studied manifest very good analgesic effect in the test involving intraperitoneal injection of glacial acetic acid. 1-Alkyl derivatives have no hypnotic effect. They potentiate hexobarbital anaesthesia (with the(More)
The effect of two doses (5 micrograms/microliters) of kainic acid (KA) injected intracortically into the posterior lateral gyrus of cats was investigated. KA in a dose of 5 micrograms/microliters provoked cortical epileptogenic focus 8-12 min after its application, developing later into a focal seizure. Administration of 10 micrograms/microliters KA(More)
Systemic administration of kainic acid in rats (30 mg/kg s.c.) and cats (5 mg/kg i.p.) produced after a definite period (30 to 60 min) secondary generalized seizures occurring first in the limbic structures (amygdala and hippocampus). The effect of N-aminomethylpiperazine-3,3-diethyl-2,4-pyridinedione (DKMP) at a dose of 100 mg/kg i.v. was evaluated on the(More)
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