T. Sejnowski

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The ionotropic glutamate receptor subunit GluR6 undergoes developmentally and regionally regulated Q/R site RNA editing that reduces the calcium permeability of GluR6-containing kainate receptors. To investigate the functional significance of this editing in vivo, we engineered mice deficient in GluR6 Q/R site editing. In these mutant mice but not in wild(More)
The basal forebrain cholinergic system is postulated to play a major role in modulating hippocampal and cortical neuron excitability, thereby controlling mechanisms critical for mediating neuronal plasticity in learning and memory. The projection of cholinergic neurons from the septal nucleus to the hippocampus is one of only two brain systems that(More)
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