T. Seiler

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Higher-order optical errors of the human eye are often responsible for reduced visual acuity in spite of an optimal spherical or cylindrical refraction. These optical aberrations are of natural origin or can result from operations on the eye involving optical structures. The presented wavefront analyzer is based on Tscherning's aberroscope. A collimated(More)
PURPOSE With the aberrometer based on Tscherning's principle, measurements of wavefront aberrations of human eyes with high accuracy and reproducibility are available for standard diagnostic investigations. METHODS During investigational and clinical trials, wavefront-aberrations of about 300 human eyes were measured and evaluated within the last few(More)
Progranulin (Pgrn) is a 88 kDa secreted protein with pleiotropic functions including regulation of cell cycle progression, cell motility, wound repair and tumorigenesis. Using microarray based gene expression profiling we have recently demonstrated that the gene for Pgrn, granulin (GRN), is significantly higher expressed in aggressive CD38(+)ZAP-70(+) as(More)
PURPOSE To determine in vivo the amount of human corneal tissue removed by each excimer laser pulse, the so-called ablation rate, during photorefractive keratectomy (PRK). There is confusion in the literature because the experimentally determined ablation rate of 0.4 to 0.5 microns per pulse differs from the nominal ablation rate of 0.23 to 0.3 microns per(More)
BACKGROUND Computer programmes for visual stimulation may give new impulses to the field of amblyopia treatment by offering an option to shift the apparative visual training into the domestic sphere. Regarding this aspect we report on a placebo controlled study on a newly developed vision training consisting of a background stimulation by a drifting(More)
The photoablative products from human cadaver corneas treated with lasers were investigated using gas chromatography and mass spectroscopy. The photoablations were done separately with an excimer laser (193 nm) and with an erbium: yttrium aluminum garnet (Er:YAG) laser (2.94 microns). More than 20 different types of molecules with a molecular weight of(More)
The relations between bulb length and the refractive power of the cornea were investigated in 3358 eyes of nonselected patients. There was a negative correlation between corneal refraction and bulb length in the range 19 to 29 mm. However, the data do not support the recently advanced hypothesis that corneal curvature and bulb length are regulated by means(More)
The visual evoked cortical potentials (VECP) of ten persons with normal vision were investigated under the influence of a nuclear magnetic resonance (NMR) field with a magnetic field strength of 0.24 T. An increase in latency of 2.09 ms for the mean value was found with weak significance and a significant increase of 2.55 ms for the median under magnetic(More)
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