T Scratcherd

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1. The role of the vagus nerves in the genesis of antro-antral reflexes was investigated in the urethane-anaesthetized, splanchnectomized ferret. 2. Antral distension stimulated antral contractions with a threshold volume of 3.5 +/- 0.9 ml (corresponding to an intra-antral pressure of 0.27 +/- 0.11 kPa) by a vagal-dependent mechanism as indicated by the(More)
1. A technique is described for perfusing the isolated cat pancreas with saline solutions.2. Single doses of secretin, although present in the perfusate for only a short time, caused a prolonged flow of pancreatic juice.3. In response to continuous secretin infusion, the preparation secreted for up to 6 hr a juice which was similar to that obtained in vivo,(More)
1. In fasted anaesthetized cats which were secreting pancreatic juice at a steady slow rate in response to continuous intravenous infusion of secretin, stimulation of the dorsal vagus trunk increased the rate of secretion, the rate of output of amylase and the concentration of bicarbonate in the juice.2. The increase in rate of secretion and in(More)
1. The effects of dibutyryl cyclic adenosine 3',5'-monophosphate (dibutyryl cyclic AMP) and theophylline have been tested in the stimulated and unstimulated perfused cat pancreas.2. Dibutyryl cyclic AMP (1.0 mM) elicited the secretion of water and electrolytes, but not of enzymes, from this preparation. The composition of this secretion was the same as that(More)
1. Extracts of antral mucosa increase the output of pancreatic amylase. They do not stimulate the resting pancreas of the anaesthetized cat to secrete juice, but have a slight ;secretin-like' effect on a pancreas already responding to endogenous or exogenous secretin.2. In animals with the vagus and splanchnic nerves cut instillation of meat extracts or(More)
1. Amylase secretion from the perfused pancreas consists of two components: a small continuous basal secretion and a stimulated secretion in response to acetylcholine or cholecystokinin-pancreozymin. The response to small doses of either stimulant was repeatable over several hours.2. The calcium concentration of pancreatic juice, always less than that of(More)
1. The rate and volume of gastric filling was estimated in conscious ferrets by measuring the amount of milk they would drink after an overnight fast. The mean volume was 94.5 +/- 7.5 ml. at a rate of 13.0 +/- 0.74 ml./min. An intragastric infusion rate of 10 ml./min to a total of 50 ml. was selected as a standard distension stimulus. 2. Action potentials(More)