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OBJECTIVE To study the effect of hyaluronic acid (HA) on local anaesthetic chondrotoxicity in vitro. METHODS Chondrocytes were harvested from bovine femoral condyle cartilage and isolated using collagenase-containing media. At 24 hours after seeding 15 000 cells per well onto a 96-well plate, chondrocytes were treated with media (DMEM/F12 + ITS), PBS, 1:1(More)
OBJECTIVES Our objective in this article is to test the hypothesis that type 2 diabetes mellitus (T2DM) is a factor in the onset and progression of osteoarthritis, and to characterise the quality of the articular cartilage in an appropriate rat model. METHODS T2DM rats were obtained from the UC Davis group and compared with control Lewis rats. The(More)
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