T S Maurer

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Membrane transporters play a significant role in the pharma-cokinetic (PK) profiles of many drugs, 1,2 to which functional genetic variations in transporters can contribute. The organic anion-transporting polypeptide 1B1 (OATP1B1), encoded by the gene SLCO1B1, is an uptake transporter expressed on the basolateral membrane of human hepatocytes. OATP1B1 has a(More)
Cytoplasmic citrate serves as an important regulator of gluconeogenesis and carbon source for de novo lipogenesis in the liver. For this reason, the sodium-coupled citrate transporter (NaCT), a plasma membrane transporter that governs hepatic influx of plasma citrate in human, is being explored as a potential therapeutic target for metabolic disorders. As(More)
Liver cirrhosis is a disease characterized by the loss of functional liver mass. Physiologically based pharmacokinetic (PBPK) modeling was applied to interpret and predict how the interplay among physiological changes in cirrhosis affects pharmacokinetics. However, previous PBPK models under cirrhotic conditions were developed for permeable cytochrome P450(More)
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