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Methamphetamine (METH) is a street drug that is abused by young people. In previous studies, we demonstrated the effectiveness of alpha-7 nicotinic receptor antagonists in preventing the neurotoxicity induced by this amphetamine derivative. The present study seeks to determine whether pre-treatment with memantine (MEM) (an antagonist of both NMDA and(More)
Many scientists are interested in the different mechanisms and strategies that animals use to navigate. This paper reviews a series of studies and models about the navigational strategies that animals can use to move from one place to another. Studies of long-distance navigation have mainly been focused on how animals are able to maintain a certain(More)
  • Ma Mercedes, T Rodrigo, Jessica O Sugay, Ryan S Baker, Emily Tabanao
  • 2009
We analyze student affect data in order to locate bottlenecks in an introductory programming course. By tracking students' affective states and behaviors over five laboratory sessions distributed over nine weeks, we find that students exhibit a significantly greater amount of confusion when expected to implement object-oriented constructs such as(More)
We present a search for standard model (SM) Higgs boson production using pp collision data at square root(s) = 1.96 TeV, collected with the CDF II detector and corresponding to an integrated luminosity of 4.8 fb(-1). We search for Higgs bosons produced in all processes with a significant production rate and decaying to two W bosons. We find no evidence for(More)
We present a search for the technicolor particles rho{T} and pi_{T} in the process pp-->rho{T}-->Wpi{T} at a center of mass energy of sqrt[s]=1.96 TeV. The search uses a data sample corresponding to approximately 1.9 fb{-1} of integrated luminosity accumulated by the CDF II detector at the Fermilab Tevatron. The event signature we consider is W-->lnu and(More)
An initial series of experiments with rats in a swimming pool established that they could find a hidden platform the location of which was defined in terms of 3 or 4 landmarks and that, when trained with all 4, any subset of 3 (or even, after a sufficient number of swimming trials, 2) landmarks was sufficient to produce accurate performance. When only one(More)
Amphetamine abuse is an important risk factor for the development of cognitive impairment involving learning and memory. Since in previous studies we have demonstrated the effectiveness of alpha-7 nicotinic receptor antagonists in preventing the neurotoxicity induced by amphetamine derivatives, the present paper seeks to determine whether pre-treatment with(More)
Glial cell line-derived neurotrophic factor (GDNF) was assayed for its neurotrophic effects against the neuronal atrophy that causes cognitive deficits in old age. Aged Fisher 344 rats with impairment in the Morris water maze received intrahippocampal injections at the dorsal CA1 area of either a lentiviral vector encoding human GDNF or the same vector(More)
The involvement of brain-derived neurotrophic factor (BDNF) in cognitive processes and the decrease in its expression in Huntington's disease suggest that this neurotrophin may play a role in learning impairment during the disease progression. We therefore analyzed the onset and severity of cognitive deficits in two different mouse models with the same(More)