T R Grishina

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A perspective direction of the treatment of dysbacteriosis is the use of so-called metabolic prebiotics--products of metabolism of positive flora (for example, water substrate of the products of metabolism of E. coli, S. faecalis, L. acidophilus, L. helveticus (strains of DSM), out of which, as known, drug Hylak Forte is made. Our earlier systematic(More)
Current fundamental research indicates importance of conducting clinical studies of the influence of magnesium content of the body on the potassium homeostasis. In this work we systematically analyze molecular mechanisms through which magnesium regulates potassium homeostasis: ATP-sensitive inward rectifier K-channels, Na+/K(+)-ATPases and their regulatory(More)
AIM Basic studies indicate magnesium deficiency as one of the important, but often neglected, risk factors aggravating the course of borderline disorders (BD). A clinical verification of this notion has been conducted. MATERIAL AND METHODS Authors studied 62 patients with BD, aged 25-65 years, of inpatient and outpatient settings. Contents of magnesium(More)
Magnesium deficiency is associated with impaired vascular tone bidirectionally and can lead to both an abnormal increase and abnormal lowering of blood pressure. This article analyzes studies on the relationship between blood pressure parameters and the level of magnesium in the blood. Evidence base for the use of magnesium for correction of vascular tone(More)
AIM To investigate the effect of cerebrolysin on the growth and metastasis of malignant tumors in mice (a model of lung carcinoma Lewis). MATERIAL AND METHODS The study was performed on 60 male mice, hybrids F1 (the age of 2-2.5 months, body weight 19-22g.). Transplantable epidermoid Lewis lung carcinoma (LLC) was used as a standard experimental model to(More)
The potassium-containing salt substitute sanasol was examined for its effects on blood pressure and renal function in normo- and hypertensive rats, as well as on the edematous syndrome in circulatory insufficiency. The antihypertensive and occasional antiedematous effects of sanasol resulted in unfavorable changes in electrolyte balance. Sanasol was found(More)
AIM To study the micronutrients that potentiate the action of anticonvulsant drugs, and in particular, of myo-inositol (vitamin B8). MATERIAL AND METHODS An experimental study of neurotrophic and anticonvulsant effects of a preparation based on myo-inositol (inofert) on thiosemicarbazide models of seizures was carried out. RESULTS Inofert significantly(More)
AIM systematization of studies of synergistic effect of potassium and magnesium on myocardial function. MATERIAL AND METHODS Analysis of an array of literature using methods of computer learning. RESULTS Synergism of potassium and magnesium is driven by common causes of deficit (low content in diet, abnormal renal function, iatrogenic causes), by(More)