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The plasma of renal transplant patients was analyzed by high performance liquid chromatography (HPLC) for the presence of azathioprine and its primary metabolite, 6-mercaptopurine, after either oral or i.v. administration of azathioprine. Azathioprine was demonstrated in plasma at peak concentrations of 0.6 microgram/ml 15 min after i.v. injections of 100(More)
GC-mass spectrometry was used to measure extremely low levels of fentanyl in dog plasma. Deuterated fentanyl was synthesized for use as an internal standard. Fentanyl was hydrolyzed to despropionyl fentanyl by 20% DCl in in deuterium oxide. Mass spectrometric analysis of the product revealed that the molecular ion was three mass units higher than that of(More)
In baboons the right cerebral hemisphere was embolised by a shower of microemboli, immediately followed by one large embolus designed to occlude the middle cerebral artery (MCA). One hour after embolism a significant, though small, reduction in blood flow and oxygen consumption of the embolised hemisphere was recorded, at which time the animals were killed(More)
The 24-h pattern of half-hourly sampled plasma cortisol in normal human subjects shows a 24-h (circadian) period, which may be variably distorted in patients who suffer from autonomous hypercortisolism (Cushing's syndrome). We have developed a pattern recognition system for computer classification of cortisol time series into the normal class and subclasses(More)
Two hundred cases of Echinochasmus liliputanus infection were randomly divided into three groups and treated with pyquiton at a single dose of 10.5 and 2.5 mg/kg, respectively. As assessed one month after treatment the egg negativity rates were 100%, 98.7% and 96.5%, respectively. The symptoms such as abdominal pain, distension, diarrhea and anorexia(More)
metrically modulated by the two categories, respectively (SOM, S5.1). The activation of the precuneus was higher for hard dominance-solvable games than for easy ones (Fig. 4A and table S10). The activation of the insula was higher for the highly focal coordination games than for less focal ones (Fig. 4B and table S11). Previous studies also found that(More)
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