T. McDonald

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Given the high costs of conducting a drug-response trial, researchers are now aiming to use retrospective analyses to conduct genome-wide association studies (GWAS) to identify underlying genetic contributions to drug-response variation. To prevent confounding results from a GWAS to investigate drug response, it is necessary to account for concomitant(More)
This paper describes an experiment in Ada design and some of the lessons learned from it. The experiment itself involved redesigning and reimplementing portions of an existing communication system. The paper compares the project team's design, based on traditional top-down structured design methods, with an alternative design based on information hiding. (More)
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