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OBJECTIVE To determine whether loss of melastatin (MLSN) is a universal phenomenon in American Joint Committee on Cancer (AJCC) stage I and II melanoma patients who experienced recurrence. MATERIAL AND METHODS Paraffin blocks of primary melanomas (PMs) were retrieved from 30 patients who had a negative sentinel lymph node biopsy and developed recurrent(More)
7517 Background: Using a radioactive in situ hybridization method on primary melanoma (PM), loss of the melastatin (MLSN-1) mRNA expression has been found to have independent prognostic significance. In this study, we examined whether a new non-radioactive chromogenic ISH (CISH) method to evaluate melastatin expression would similarly predict PM outcome. (More)
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