T. M. Makarova

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The influence of extremely low frequency magnetic field on rats behavior (working memory, learning, social activity) was examined. Rats were exposed to magnetic fields at three different conditions: exposure 1-50 Hz, 46 mT; DC 65 mTl; exposure II-50 Hz, 46 mTl; DC 14-17 mTl; Exposure III-sham. Field related changes were observed after exposure I: the(More)
Rats behaviour in the "open field" changed in 2 hrs after a single episode of hypoglycaemia was abolished with glucose whereas no changes occurred in their stereotyped behaviour and intraspecies interaction. In 24 hrs quantitative parameters of the "open field" behaviour normalised although the behaviour still had an altered structure. At the same time,(More)
The ribosome as a complex molecular machine undergoes significant conformational changes while synthesizing a protein molecule. Molecular dynamics simulations have been used as complementary approaches to X-ray crystallography and cryoelectron microscopy, as well as biochemical methods, to answer many questions that modern structural methods leave unsolved.(More)
It has been found that among white outbred rats with different experience of intraspecies contact four types of reaction to the partner are singled out in the "stranger-resident" test: active, neutral passive, highly-aggressive. Belonging to one or another type is determined by the level and correlation of aggression and intraspecies sociability. Among(More)
We studied the influence of social isolation at the age of 2 months on zoosocial behaviour of mixed-bred male rats with different paw preference. Paw preference was determined in the test of reaching for food in the horizontal tube. The level of aggression but not sociability was found to increase significantly in dextral and ambidextrous late isolants. In(More)
Using a method of static simulation, a series of erythromycin A analogs was designed with aldehyde functions introduced instead of one of the methyl substituents in the 3′-N-position of the antibiotic that was potentially capable of forming a covalent bond with an amino group of one of the nucleotide residues of the 23S rRNA in the ribosomal exit tunnel.(More)
By means of the analysis of probabilistic ethological structures of the intraspecies rats behaviour in the test "stranger-resident" and by the method of isolated destruction of the frontal cortex or the left and right hemispheres,--it is established that the frontal cortex of the left hemisphere regulates the intraspecies sociability and keeps it on a(More)
The paper provides a comprehensive hygienic assessment of the levels of the essential and toxic trace elements chosen in terms of regional features in drinking water and foodstuffs of locally manufactured products. Priority pollutants of drinking water and foodstuffs are defined in the eastern, western, and central lands of the Orenburg Region. A(More)