T M Biagioni

Learn More
Administration of single doses of ethanol or presence of ethanol in the incubation medium does not change 3H-flunitrazepam binding in rat cerebral cortex, hippocampus and cerebellum. In rats made dependent on ethanol by three daily ethanol administrations for six days and sacrifices 1 hr after the last ethanol dose 3H-flunitrazepam binding is decreased in(More)
Sodium independent GABA receptor binding was measured in synaptosomes prepared from cerebral cortex of rats made ethanol dependent by three daily ethanol administrations. In rats sacrificed 1 hour after the last ethanol dose there was a lower number of low affinity binding sites and lower affinity of the high affinity binding than in controls. The decreased(More)
In vitro binding assays to measure muscarinic receptor number and affinity were carried out with isolated synaptic plasma membranes from bovine caudate nuclei. Diethyl-p-nitrophenyl phosphate (paraoxon; PX), dichlorvos (DDVP), and tetraethyl pyrophosphate (TEPP) were demonstrated to be weak noncompetitive receptor inactivators. PX, DDVP, and TEPP decreased(More)
Characteristics of receptor binding of diazepam and flunitrazepam in three brain areas were compared. It was found that in the cerebral cortex and cerebellum the number of sites was similar for both ligands and that the affinity of diazepam was four times lower than the affinity of flunitrazepam. In contrast, when binding in the hippocampus was analyzed(More)
  • 1