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Cardiomyocyte death is an important reason for the cardiac syndromes, such as heart failure (HF) and myocardial infarction (MI). In the heart diseases, necrosis is one of the main forms of cell death. MicroRNAs (miRNAs) are a class of small non-coding RNAs that mediate post-transcriptional gene silencing. Hitherto, it is not yet clear whether miRNA can(More)
Doxorubicin (DOX) is a wide-spectrum antitumor drug, but its clinical application is limited by its cardiotoxicity. However, the mechanisms underlying DOX-induced cardiomyopathy remain mostly unclear. Here we observed that apoptosis repressor with caspase recruitment domain (ARC) was downregulated in mouse heart and cardiomyocytes upon DOX treatment.(More)
Cytosolic free Ca2+ ([Ca2+]i) in suspended brain cells of chicken embryos hatched for 6-18 d (E6-E18) was measured by using the fura-2/AM fluorescence spectroscopy. The biological effects of microgravity on the embryonic chicks were simulated by revolving on a clinostat during their hatch. The experimental results showed that level of [Ca2+]i in E8-E17(More)
Morphological changes of hepatocyte death have so far only been described on cells in culture or in tissue sections. Using a high-resolution and high-magnification multiphoton microscopic system, we recorded in living mice serial changes of acetaminophen (APAP)-induced hepatocyte necrosis in relevance to metabolism of a fluorogenic bile solute. Initial(More)
Here is reported in situ observation of energetic electrons (∼100-500 keV) associated with magnetic reconnection in the solar wind by the ACE and Wind spacecraft. The properties of this magnetic cloud driving reconnection and the associated energetic electron acceleration problem are discussed. Further analyses indicate that the electric field acceleration(More)
Intracellular free Ca(2+) concentration ([Ca(2+)](i)) in embryonic chick cerebellar granule cells loaded with fluo-3/AM and exposed to a single pulsed electric field was investigated using a confocal laser scanning microscope and fluorescent microscope equipped with CCD video imaging system. The results showed that [Ca(2+)](i) increased immediately and rose(More)
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