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It has been suggested that matrix metalloproteinase-3 (MMP-3, stromelysin-1) has an important role in the degeneration of intervertebral discs (IVDs). A human MMP-3 promoter 5A/6A polymorphism was reported to be involved in the regulation of MMP-3 gene expression. We suggest that IVD degeneration is associated with 5A/6A polymorphism. We studied 54 young(More)
Scleraxis is a basic helix-loop-helix-type transcription factor that is expressed in sclerotome. Fibroblast growth factor (FGF) is one of the cytokines produced by the cells in skeletal tissues and is a potent modulator of skeletogenesis. The aim of this study was to examine the effects of FGF on the expression of scleraxis in chondrocyte-like cells, TC6.(More)
STUDY DESIGN The functional recovery of rats that underwent spinal cord transection in infancy was evaluated by multimodal examination (functional tests, electrophysiologic evaluation, tract-tracing) to determine the basis for the recovery. OBJECTIVES To determine whether the hind limb function in rats that underwent spinal cord transection in infancy is(More)
Transforming growth factor-β1 (TGFβ1)-stimulated clone 22 (TSC-22) is a primary response gene isolated by subtractive screening of genes expressed in murine osteoblastic cells treated with TGFβ1, which is one of the cytokines abundantly stored in bone. Fibroblast growth factor (FGF) is also stored in bone matrix and acts as a potent autocrine/paracrine(More)
Posterior longitudinal ligament (PLL) in cervical spine is one of the sites of ossification in idiopathic hyperostotic diseases. Although the mechanism of the pathological triggering of the disease has not yet been clarified, the cells in PLL have been reported to express osteotropic cytokines such as BMP-2 and TGF-β. However, it has not been known whether(More)
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