T. John

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Synovial fibroblasts (SF) contribute to the pathogenesis of osteoarthritis (OA), but the effects of intra-articular cytokines on SF are not completely understood. The aim of this study was to characterize the interplay between tumor necrosis factor (TNF)α and the anti-inflammatory interleukin (IL)-10. Non-immortalized human SF and SF of the human cell line(More)
The spirit of systems pharmacology was adopted to study the possible mechanisms of anxiolytic drugs on hippocampal electric patterns. The frequency of the hippocampal theta rhythm increases linearly with the intensity of electrical stimulation to the brainstem. The reduction of mean theta frequency in this paradigm predicts the clinical efficacy of(More)
In this paper, we propose a POD-based technique that is suitable for the design of reliable observers for the estimation of velocity field and contaminant flow for Navier–Stokes flow. POD modes are constructed using the method snapshot. Karhunen–Loeve (Galerkin) projection to develop a reduced-order model obtained by projecting the velocity field onto the(More)
The spirit of systems pharmacology was adopted to study the possible mechanisms of anxiolytic drugs on hippocampal electric patterns. The frequency of the hippocampal theta rhythm increases linearly with the intensity of electrical stimulation to the brain-stem. The reduction of mean theta frequency in this paradigm predicts the clinical efficacy of(More)
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