T. I. Oleshko

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Tetraphenyl porphyrin (TPP) and its complexes with Fe3+, Co2+, Cu2+, Zn2+ and Ni2+ inhibited cytochrome P-450-dependent enzymes in rat liver microsomes. Content of cytochrome P-450 was decreased by 27% or 49% depending on the substance administered (TPP or its metal complexes, respectively). N-demethylase was inactivated by about 30%; the rate of aniline(More)
Effects of low-intensive infrared laser (890 nm) exposure on lipid peroxidation (LPO) and antioxidant system (AOS) activity in the membrane fraction of hepatocyte endoplasmatic reticulum (microsomal fraction of the liver) were studied in a physiologically balanced LPO/AOS system (intact animals) and under conditions of LPO initiation by immobilization cold(More)
It is shown that tetraphenylporphyrin (TPP) and its complexes with metals decrease the rate of the diene conjugate formation. The above compounds increase the malonic dialdehyde accumulation. The effect of TPP and its complexes with metals is connected with stimulation of lipid peroxidation in biomembranes.
The intensive study of inducers of microsomal mono-oxygenases (MOG) is linked with prospects for creating substances on their basis which will stimulate detoxication processes and protect the internal medium of the organism against xenobiotics of varied nature. Effective inducers of MOG (as well as inhibitors) can also be used to control, at the molecular(More)
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