T Helfrich

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The rostro-caudal extent of odorant receptor expression zones in the rat olfactory epithelium was analysed by means of in situ hybridization. Three broad non-overlapping zones were identified that extended along almost the entire anterior-posterior axis; each zone was composed of several separate bands running anterior to posterior throughout the olfactory(More)
In situ hybridization approaches have been employed to explore the onset and time course of odorant receptor expression during the prenatal development of rats. The critical phase for the maturation of the olfactory system from embryonic day (E) 12 to E18 was analysed. The onset of expression of four receptor genes (OR5, OR14, OR37 and OR124) was found(More)
In situ hybridization techniques have been employed to explore the olfactory epithelium of the rat for the distribution of odorant receptor gene transcripts. We demonstrate that olfactory neurone subpopulations expressing distinct receptor subtypes are spatially segregated within the olfactory epithelium. A compartmentalization of the neuroepithelium into(More)
63. Transmembrane-type guanylyl cyclases may also contribute to chemosensation. Guanylyl cyclase-D is expressed in a restricted subset of rodent OSNs that project to necklace glomeruli [H. The genome of C. elegans has 29 guanylyl cyclases, some of which are expressed in che-mosensory neurons (Their roles and ligands are not known. 64. I thank L. Buck and R.(More)
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