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Dynamics are playing an increasingly important role in many engineering domains as these systems become more active and autonomous. Designing a dynamic engineering system can be challenging. In this thesis, both the problem formulation and solution methods will be discussed for designing a dynamic engineering system. A case is made for the inclusion of both(More)
Design of physical systems and associated control systems are coupled tasks; design methods that manage this interaction explicitly can produce system-optimal designs, whereas conventional sequential processes may not. Here, we explore a new technique for combined physical and control system design (co-design) based on a simultaneous dynamic optimization(More)
1. Abstract Synthetic biology is a field that involves design of artificial biological devices and systems with the objective of achieving specific biological functions. While a large number of synthetic biological systems have been created over the years, current design methods are limited in the complexity of systems that can be developed. Here we focus(More)
In this thesis, we present two approaches for designing genetic regulatory networks in the field of synthetic biology. The core problem is to capture topological properties and dynamical mechanisms in such a way that enables generation of large-scale and complex genetic regulatory networks. Synthetic biologists design and construct artificial biological(More)
A newmethod is presented for biochemical enzyme network design based on direct transcription and mathematical programs with complementarity constraints. Topology and continuous parameters are optimized simultaneously. The case study design objective is to optimize adaptability while maintaining sufficient sensitivity to ensure input change detection. A(More)
∗Graduate student, Department of Industrial and Enterprise Systems Engineering, University of Illinois at Urbana-Champaign, guo32@illinois.edu †Graduate student, Language Technologies Institute, Carnegie Mellon University, jiaruix@cs.cmu.edu ‡Graduate student, Department of Computer Science, University of Illinois at UrbanaChampaign, yuesun3@illinois.edu(More)
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