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A Bayesian method is described for reconstruction of high-resolution 3D images from the microPET small-animal scanner. Resolution recovery is achieved by explicitly modelling the depth dependent geometric sensitivity for each voxel in combination with an accurate detector response model that includes factors due to photon pair non-collinearity and(More)
UNLABELLED A new dedicated PET scanner, microPET, was designed and developed at the University of California, Los Angeles, for imaging small laboratory animals. The goal was to provide a compact system with superior spatial resolution at a fraction of the cost of a clinical PET scanner. METHODS The system uses fiberoptic readout of individually cut(More)
A fully 3D Bayesian method is described for high resolution reconstruction of images from the Siemens/CTI ECAT EXACT HR+ whole body positron emission tomography (PET) scanner. To maximize resolution recovery from the system we model depth dependent geometric efficiency, intrinsic detector efficiency, photon pair non-colinearity, crystal penetration and(More)
UNLABELLED Receiver operating characteristic (ROC) and localization ROC (LROC) studies were performed to compare lesion detection at the borderline of detectability on images reconstructed with two-dimensional filtered backprojection (FBP) without attenuation correction (a common clinical protocol), three-dimensional FBP without attenuation correction,(More)
UNLABELLED Image quality in PET is typically assessed using measures such as contrast recovery, noise variation, and signal-to-noise ratio (SNR). However, these criteria do not directly reflect performance in the clinical use of the images. Lesion detection is a critical task in the clinical interpretation of many PET studies. A receiver operating(More)
MicroPET is a low-cost, high-resolution positron emission tomography (PET) scanner designed for imaging small animals. MicroPET operates exclusively without septa, acquiring fully three-dimensional (3-D) data sets. The performance of the projection-reprojection (3DRP), variable axial rebinning (VARB), single slice rebinning (SSRB), and Fourier rebinning(More)
A fully 3D Bayesian method is described for high resolution reconstruction of images from the Siemens/CTI ECAT EXACT HR+ whole body positron emission tomography (PET) scanner. To maximize resolution recovery from the system we model depth dependent geometric efficiency, intrinsic detector efficiency, photon pair non-colinearity, crystal penetration and(More)
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