Materials that can be described as respirable granular biodurable particles without known significant specific toxicity (GBP) show a common mode of toxicological action that is characterized by inflammation and carcinogenicity in chronic inhalation studies in the rat. This study was carried out to compare the carcinogenic potency of GBP nanomaterials… (More)
Gebel (2012) performed a quantitative review of inhalation rat studies on the association of granular biopersistent dust exposures and lung cancer risk. The analytical methods applied are unreliable because they do not fulfil the requirements of current meta-analytical methods.
Part of the northern Palatinate region in Germany is characterized by elevated levels of arsenic and antimony in the soil due to the presence of ore sources and former mining activities. In a biomonitoring study, 218 residents were investigated for a putative increased intake of these elements. Seventy-six nonexposed subjects in a rural region in south… (More)
Nanotechnology offers enormous potential for technological progress. Fortunately, early and intensive efforts have been invested in investigating toxicology and safety aspects of this new technology. However, despite there being more than 6,000 publications on nanotoxicology, some key questions still have to be answered and paradigms need to be challenged.… (More)
nanotoxicology revolution, and as a result, necessary to summarize what we have learned in the past years and which questions still remain open. No evidence for nano‑specific toxicity Although it has been suggested that nanoparticles should 'be tested individually' (Krug and Wick 2011), we see no evidence that nano-specific toxic mechanisms exist (review:… (More)
Arsenic is a human carcinogen that occurs ubiquitously in soil and water. Based on epidemiological studies, a benchmark dose (lower/higher bound estimate) between 0.3 and 8 μg/kg bw/day was estimated to cause a 1 % increased risk of lung, skin and bladder cancer. A recently published study by EFSA on dietary exposure to inorganic arsenic in the European… (More)
Nanotechnology represents one of the key technologies of the twenty-first century and includes all methods that allow production, and analysis of objects sized between one and 100 nm. A large number of nanomaterials and consumer products are already used, such as paints, car tyres, tennis rackets, textiles and sunscreens. Technologically more important than… (More)