T. G. Spence

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Over the last two decades, it has been recognized that head and neck cancers, primarily in the oropharynx, can be a distinct entity that is causally related to human papilloma virus (HPV). Fakhry et al. established in 2008 that such tumors have a strikingly better prognosis with improved responsiveness to chemotherapy as well as chemoradiotherapy and(More)
BACKGROUND Embryonal tumor with multilayered rosettes (ETMR) is an aggressive central nervous system primitive neuroectodermal tumor (CNS-PNET) variant. ETMRs have distinctive histology, amplification of the chromosome 19 microRNA cluster (C19MC) at chr19q13.41-42, expression of the RNA binding protein Lin28, and dismal prognosis. Functional and therapeutic(More)
Amplification of the C19MC oncogenic miRNA cluster and high LIN28 expression has been linked to a distinctly aggressive group of cerebral CNS-PNETs (group 1 CNS-PNETs) arising in young children. In this study, we sought to evaluate the diagnostic specificity of C19MC and LIN28, and the clinical and biological spectra of C19MC amplified and/or LIN28+(More)
A system is described that employs a diode-pumped Nd:YAG continuous-wave laser source servolocked to a three-mirror optical cavity and an analog detection circuit that extracts the ring-down rate from the exponentially decaying ring-down waveform. This scheme improves on traditional cavity ring-down spectroscopy setups by increasing signal acquisition rates(More)
In this paper we present and discuss the thinning of antenna arrays that are based on aperiodic tilings. Aperiodic tilings are a class of tilings that cover the plane without gaps or overlaps and do not exhibit any long-range translational symmetry. By utilizing these tilings in array design it is possible to generate naturally thinned arrays that exhibit(More)
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