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We examined the effects of chronic activity wheel running on brain monoamines and latency to escape foot shock after prior exposure to uncontrollable, inescapable foot shock. Individually housed young (approximately 50 day) female Sprague-Dawley rats were randomly assigned to standard cages (sedentary) or cages with activity wheels. After 9-12 weeks,(More)
Regional changes in concentrations of brain norepinephrine [NE] and its metabolites after chronic exercise have not been described for exercise protocols not confounded by other stressors. We examined levels of [NE], 3-methoxy-4-hydroxyphenylglycol [MHPG], and 3,4-dihydroxyphenylglycol [DHPG] in the frontal cortex, hippocampus, pons-medulla, and spinal cord(More)
The central nervous system is the principal target of 1,1,1-trichloroethane (TRI), and several studies of this volatile solvent have demonstrated effects on learned animal behaviors. There have been few attempts, however, to quantitatively relate such effects to blood or target organ (brain) solvent concentrations. Therefore, Sprague-Dawley rats trained to(More)
Dose-dependent increases in 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MOPEG-SO4), a major metabolite of norepinephrine, were produced in the limbic forebrain and cerebral cortex 30 min after the bilateral injection of morphine into the periaqueductal gray (PAG). These effects were also elicited by similar injections of levorphanol. Highly significant(More)
Previous studies have indicated that human exposure to perchloroethylene (PCE) produces subtle behavioral changes and other neurological effects at concentration at or below the current occupational exposure limit. Since comparable effects in animals may be reflected by changes in schedule-controlled operant behavior, the ability of orally administered PCE(More)
Analgesia and changes in limbic and cortical concentrations of the major brain noradrenaline metabolite, 3-methoxy-4-hydroxy-phenylethylene glycol sulphate (MOPEG-SO4), were investigated in rats following the bilateral injection of morphine into the periaqueductal gray (PAG). Morphine, at a dose of 5 micrograms per bilateral site, produced a significant(More)
The acute and chronic effects of morphine on the turnover of norepinephrine (NE) were determined by measuring the changes in the levels of the sulfate conjugate of 3-methoxy-4-hydroxyphenylglycol (MHPG-SO4) in rat brain. Two hours after administration, morphine produced a dose-related increase in the levels of MHPG-SO4 suggesting an increase in NE turnover.(More)