Learn More
Degeneration of cholinergic neurons in the basal forebrain (CBF) is a prominent neuropathological feature of Alzheimer's disease and is thought responsible for some cognitive deficits seen in patients. An animal model of pure CBF degeneration would be valuable for analysis of the function of these neurons and testing therapeutic strategies. CBF neurons(More)
Intraventricular injection of 192-saporin, an immunotoxin directed at the low affinity neurotrophin receptor (p75NGFr), selectively destroys cholinergic neurons in the basal forebrain (CBF). In the present study, we sought to determine if there was a correlation between degree of CBF neuron destruction and degree of passive avoidance behavioral impairment.(More)
  • 1