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There is conjoining experimental and clinical evidence supporting a fundamental role of the basal ganglia as a sensory analyser engaged in central somatosensory control. This study was aimed at investigating the functional anatomy of sensory processing in two clinical conditions characterized by basal ganglia dysfunction, i.e. Parkinson's and Huntington's(More)
Rheopheresis is a specific application of membrane differential filtration, synonymous with double filtration plasmapheresis for extracorporeal hemorheotherapy, eliminating an exactly defined spectrum of high molecular weight proteins from human plasma (e.g.: fibrinogen, alpha-2-macroglobulin, low-density lipoprotein cholesterol, IgM). This results in the(More)
Rheopheresis is a specific application of membrane differential filtration, synonymous with double filtration plasmapheresis, for extracorporeal hemorheotherapy. Safety and efficacy of Rheopheresis for wound healing and skin oxygenation were investigated in patients with ischemic diabetic foot syndrome. Eight patients with type 2 diabetes mellitus and(More)
Extracorporeal low-density lipoprotein (LDL) apheresis is an established and highly effective therapy for patients with familial hypercholesterolemia (FH) not adequately responding to diet and drug therapy alone. Based on different methodology, five treatment options of LDL apheresis are available and in widespread practical use in Germany. All methods are(More)
In the majority of age-related macular degeneration (AMD) patients the therapeutic situation is very unsatisfactory, especially for patients with dry AMD. Rheopheresis is a safe and effective modality of therapeutic apheresis to treat microcirculatory disorders, and represents a novel therapeutic approach for patients with dry AMD and soft drusen.(More)
Low density lipoprotein (LDL) apheresis is an effective treatment option for patients with severe hypercholesterolemia not adequately responding to diet and drug therapy. Membrane differential filtration (MDF), synonymous with double filtration plasmapheresis (DFPP), here named Lipidfiltration, and heparin-induced extracorporeal LDL-precipitation (HELP) are(More)
The aim of this investigation is the evaluation of DLR for the radiological diagnosis of intrapulmonary coin lesions. For this, a DLR system was used which had been specially developed for chest radiography. Early results were unsatisfactory and therefore specific image parameters were developed. The scope for dose reduction was also investigated. Oncology(More)
A simple experimental technique for interstitial iridium-192 high dose-rate afterloading is described which allows to perform experimental brachytherapy on a rat tumor model. To illustrate the possibilities and limitations of the technique, rhabdomyosarcoma R1H of the rat were subjected to a combined brachy- and teletherapy treatment applying a total dose(More)
Rhabdomyosarcoma R1H of the rat with a volume of 1.2 cm3 were treated by implanting three to eight iodine-125 seeds (20.4 MBq). While implantation of inactive seeds had no influence on tumour growth, implantation of three or four seeds caused a reduction in tumour growth rate. Local tumour control was achieved in 71 and 80% of the tumours after implantation(More)