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The synaptic vesicle cycle sustains neurotransmission and keeps pace between exo- and endocytosis in synapses. GTP-binding proteins function as key regulators of this cycle. The large GTPase dynamin is implicated in fission of clathrin-coated vesicles from the presynaptic membrane during endocytosis. The present study addresses the effect of the(More)
Ultrastructural changes of rat diaphragm muscle fibers were studied after administration of chlorophos, i. e. organophosphorus inhibitor. Observations were made 10-180 seconds after treatment (concentrations--18 and 24 mM). The swelling of mitochondria and the increase in the length of sarcomeres were observed simultaneously. These changes were phasic. The(More)
As it was revealed by electron microscopic study, phenazepam (benzodiazepine representative) administered to rats in acute toxic dose caused astrocyte processes swelling mainly in reticular portion of substantia nigra and cerebral areas with high density of GABAergic synapses in initial intoxication stage (one hour after the drug introduction). Following 24(More)
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