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The synaptic vesicle cycle sustains neurotransmission and keeps pace between exo- and endocytosis in synapses. GTP-binding proteins function as key regulators of this cycle. The large GTPase dynamin is implicated in fission of clathrin-coated vesicles from the presynaptic membrane during endocytosis. The present study addresses the effect of the(More)
As it was revealed by electron microscopic study, phenazepam (benzodiazepine representative) administered to rats in acute toxic dose caused astrocyte processes swelling mainly in reticular portion of substantia nigra and cerebral areas with high density of GABAergic synapses in initial intoxication stage (one hour after the drug introduction). Following 24(More)
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