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BACKGROUND Human-activated protein C (APC) is a serine protease with anticoagulant, anti-inflammatory and cytoprotective functions. This feature renders APC to be a promising vascular-inflammatory biomarker. OBJECTIVE The aim of the present study was the development and validation of a technique that allows the measurement of APC plasma levels under(More)
Both IL-1 alpha and IL-1 beta lack an N terminus secretory sequence, and the mechanism of secretion of these pleiotropic cytokines is incompletely understood. The epidermis contains large quantities of IL-1 alpha in keratinocytes, which may play a role in inducing endothelial adhesion molecules and promoting extravasation of leukocytes. Here we report that(More)
Multiple system failure is often the final result of severe infection that cannot be controlled. The changes that may occur in remote organs and cells in the early stages of sepsis and that may initiate this process have not been defined. To study this, indocyanine green (ICG) clearance, serum enzyme levels, and reticuloendothelial (RE) function were(More)
S | Adaptive Immunity & Vaccination S2 Journal of Investigative Dermatology (2015), Volume 135 007 Phenotypic analysis of dendritic cells infiltrating a spontaneous model of basal cell carcinoma C Nirschl , Y Liu , P Wu , K Haitz 2 and N Anandasabapathy 2 1 Department of Dermatology, Brigham and Women’s Hospital, Boston, MA and 2 Harvard Medical School,
Based on the concepts of Sylvester matrix and Sylvester resultant elimination, sufficient and necessary conditions are developed for the delay-independent stability of a class of delayed systems with commensurate delays, and an effective algorithm is presented for computing the minimal critical value T such that within the delay interval (0, T), the system(More)
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