Learn More
OBJECTIVE Cerebrospinal fluid (CSF) neurofilament light chain (NfL) concentration is elevated in neurological disorders, including frontotemporal degeneration (FTD). We investigated the clinical correlates of elevated CSF NfL levels in FTD. METHODS CSF NfL, amyloid-β1-42 (Aβ42), tau, and phosphorylated tau concentrations were compared in 47 normal(More)
Introduction Many people associate virtual reality and computer simulations with science fiction, high-tech industries, and computer games; few associate these technologies with education. But virtual reality and computer simulations have been in use as educational tools for some time. Although they have mainly been used in applied fields such as aviation(More)
Nous caract erisons les syst emes radicaux de congruences sur les semi-groupes nis, qui sont en m^ eme temps des syst emes de plus grandes congru-ences sur une pseudovari et e x ee. Abstract We characterize all the radical congruence systems for nite semigroups which are systems of greatest congruences over some pseudovariety. A congruence system is a(More)
Eilenberg has shown that there is a one-to-one correspondence between varieties of finite monoids and varieties of recognizable languages. In this paper, we give a description of a variety of languages close to the class of piecewise testable languages considered by I. Simon. The corresponding variety of monoids is the variety of J-trivial monoids with(More)
Alzheimer's disease is the most prevalent cause of dementia and is associated with accumulation of amyloid-β peptide (Aβ), particularly the 42-amino acid Aβ1-42, in the brain. Aβ1-42 levels can be decreased by γ-secretase modulators (GSM), which are small molecules that modulate γ-secretase, an enzyme essential for Aβ production. BMS-869780 is a potent GSM(More)
This study is drawn from a work programme aimed at developing improved medical counter measures for nerve agent poisoning. Guinea-pigs were administered pyridostigmine (5.1 microg/h) or physostigmine (4.7 microg/h) and hyoscine (1.94 microg/h) for 6 days via a subcutaneously implanted mini osmotic pump. Pyridostigmine inhibited red cell acetylcholinesterase(More)
It is shown that the embeddability of a nite 4-nilpotent semigroup into a 0-simple nite semigroup with maximal groups from a pseudovariety V is decidable if and only if the universal theory of the class V is decidable. We show that it is impossible to replace 4 by 3 in this statement. We also show that if the membership in V is decidable then the membership(More)
BACKGROUND Elevated CSF τ is considered a biomarker of neuronal injury in newly developed Alzheimer's disease (AD) and mild cognitive impairment (MCI) criteria. However, previous studies have failed to detect alterations of τ species in other primary tauopathies. We assessed CSF τ protein abnormalities in AD, a tauopathy with prominent Aβ pathology, and(More)