Learn More
The syntheses and full retinoid receptor characterization of a novel series of retinoic acid receptor alpha (RAR alpha) antagonists, 1-5, are described. These compounds bind with high affinity to RAR alpha but were completely inactive in gene transactivation. They were also potent and effective antagonists of retinoic acid (RA) induced gene transcription at(More)
Hardware to implement feedforward neural networks has been developed for the evaluation of learning algorithms and prototyping of applications. To allow the construction of networks with arbitrary architectures, CMOS VLSI building-block components (e.g. arrays of neurons and synapses) have been designed. These can be cascaded to form networks with hundreds(More)
Cascadable, CMOS synapse chips containing a cross-bar array of 32x32 (1024) programmable synapses have been fabricated as "building blocks" for fully parallel implementation of neural networks. The synapses are based on a hybrid digital-analog design which utilizes on-Chip 7-bit data latches to store quantized weights and two-quadrant multiplying DAC's to(More)
Design and synthesis of nonpeptidal bis-tetrahydrofuran ligands based upon the X-ray crystal structure of the HIV-1 protease-inhibitor complex 1 led to replacement of two amide bonds and a 10 pi-aromatic system of Ro 31-8959 class of HIV protease inhibitors. Detailed structure-activity studies have now established that the position of ring oxygens, ring(More)
Researchers at Sandia National Laboratories and the U.S. Department of Energy’s Solar Energy Technologies Program assessed status and needs related to optimizing the integration of electrical energy storage and gridconnected photovoltaic (PV) systems. At high levels of PV penetration on our electric grid, reliable and economical distributed energy storage(More)
Retinoids are analogues of all-trans-retinoic acid, a powerful hormone that mediates many fundamental biological processes. Cancer and other serious hyperproliferative diseases are attractive therapeutic targets for retinoids, but the therapeutic use of retinoids is limited due to severe toxicity. We report here the design of retinoid receptor-alpha(More)
An electronic neural network for the Euclidean distance minimization problem, implemented in VLSI-based hardware, is described. The convergence properties of the neural-network hardware are investigated and compared with computer simulation results. The neural network's ability to find the 'best' or a 'good' solution is quickly demonstrated. The effect of(More)
In 2005 Kempton and Tomic laid out a vision for V2G which presumed that use of V2G technology could provide a high revenue stream to early plug-in electric vehicles, enabling market penetration of relatively high cost, early-to-market electric drive vehicles. The descriptions of performance requirements of plugin hybrids (PHEVs) and electric vehicles (EVs)(More)
A series of protease inhibitors bearing constrained unnatural amino acids at the P2-position and novel heterocycles at the P3-position of compound 1 (Ro 31-8959) were synthesized, and their in vitro enzyme inhibitory and antiviral activities were evaluated. Replacement of P2-asparagine of compound 1 with (2S,3'R)-tetrahydrofuranylglycine resulted in(More)