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The existence of enteric dopaminergic neurons has been suspected; however, the innervation of the gut by sympathetic nerves, in which dopamine (DA) is the norepinephrine precursor, complicates analyses of enteric DA. We now report that transcripts encoding tyrosine hydroxylase (TH) and the DA transporter (DAT) are present in the murine bowel (small(More)
The hypothesis was tested that developing enteric neurons withdraw from the cell cycle in a sequence related to their phenotype. The birthdays of immunocytochemically identified myenteric and submucosal neurons were determined in the murine duodenum and jejunum. [3H]thymidine ([3H]TdR) was injected into timed pregnant mice or pups at 4-8 hour intervals over(More)
Neurotrophin-3 (NT-3) promotes enteric neuronal development in vitro; nevertheless, an enteric nervous system (ENS) is present in mice lacking NT-3 or TrkC. We thus analyzed the physiological significance of NT-3 in ENS development. Subsets of neurons developing in vitro in response to NT-3 became NT-3 dependent; NT-3 withdrawal led to apoptosis,(More)
Enteric and sympathetic neurons have previously been proposed to be lineally related. We present independent lines of evidence that suggest that enteric neurons arise from at least two lineages, only one of which expresses markers in common with sympathoadrenal cells. In the rat, sympathoadrenal markers are expressed, in the same order as in sympathetic(More)
The lethal spotted mutant mouse (ls/ls) develops congenital megacolon because of the absence of ganglia in the terminal colon. This aganglionosis results from a failure of neural crest cells to colonize this area during fetal life. We have postulated that the microenvironment of the aganglionic segment of bowel is abnormal. Our hypothesis suggests that this(More)
Spherical radial basis functions are used to define approximate solutions to strongly elliptic and elliptic pseudodifferential equations on the unit sphere. These equations arise from geodesy. The approximate solutions are found by the Galerkin and collocation methods. A salient feature of the paper is a unified theory for error analysis of both(More)
Spherical radial basis functions are used to define approximate solutions to pseudodifferential equations of negative orders on the unit sphere. These equations arise from geodesy. The approximate solutions are found by the collocation method. A salient feature of our approach in this paper is a simple error analysis for the collocation method using the(More)
Spherical radial basis functions are used to define approximate solutions to strongly elliptic pseudodifferential equations on the unit sphere. These equations arise from geodesy. The approximate solutions are found by the Galerkin and collocation methods. A salient feature of the paper is a unified theory for error analysis of both approximation methods.