T. C. Tai

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Numerous studies have demonstrated the importance of naturally occurring dietary polyphenols in promoting cardiovascular health and emphasized the significant role these compounds play in limiting the effects of cellular aging. Polyphenols such as resveratrol, epigallocatechin gallate (EGCG), and curcumin have been acknowledged for having beneficial effects(More)
Oxidative damage is considered to be the primary cause of several aging associated disease pathologies. Cumulative oxidative damage tends to be pervasive among cellular macromolecules, impacting proteins, lipids, RNA and DNA of cells. At a systemic level, events subsequent to oxidative damage induce an inflammatory response to sites of oxidative damage,(More)
Perinatal changes in plasma prostaglandin E2 (PGE2) act at the level of the fetal brainstem to modulate respiratory activity. In-vitro receptor autoradiography was used to determine whether PGE2 binding sites (putative receptors) are located in brainstem regions responsible for respiratory control. Frozen brainstem sections were obtained from fetal sheep at(More)
Metabolic activity of specific brain regions (e.g. brainstem respiratory centers) may increase during the physiologic adaptations at birth. Since regional activity of cytochrome oxidase is correlated with the level of oxidative metabolism, cytochrome oxidase histochemistry was used to investigate whether there are sustained changes in metabolic activity(More)
The catecholamine epinephrine is physiologically important in cardiac function and blood pressure regulation. Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway, responsible for epinephrine biosynthesis, and is primarily localized in the adrenal gland. In hypertensive rats, adrenal PNMT mRNA,(More)
Reactive oxygen species trigger cardiomyocyte cell death via increased oxidative stress and have been implicated in the pathogenesis of cardiovascular diseases. The prevention of cardiomyocyte apoptosis is a putative therapeutic target in cardioprotection. Polyphenol intake has been associated with reduced incidences of cardiovascular disease and better(More)
Epinephrine is synthesised by the catecholamine biosynthetic enzyme, phenylethanolamine N-methyltransferase (PNMT), primarily in chromaffin cells of the adrenal medulla and secondarily in brainstem adrenergic neurons of the medulla oblongata. Epinephrine is an important neurotransmitter/neurohormone involved in cardiovascular regulation; however,(More)
The stress hormone, epinephrine, is produced predominantly by adrenal chromaffin cells and its biosynthesis is regulated by the enzyme phenylethanolamine N-methyltransferase (PNMT). Studies have demonstrated that PNMT may be regulated hormonally via the hypothalamic-pituitary-adrenal axis and neurally via the stimulation of the splanchnic nerve.(More)
BACKGROUND The renal renin-angiotensin system (RAS) is physiologically important for blood pressure regulation. Altered regulation of RAS-related genes has been observed in an animal model of hypertension (spontaneously hypertensive rats - SHRs). The current understanding of certain RAS-related gene expression differences between Wistar-Kyoto rats (WKYs)(More)
Expression in sheep brain of EP transcripts and their ontogeny in the brainstem was determined using RT-PCR. Sheep EP subtypes showed high homology (>80%) with other species. EP1, EP2, EP3 and EP4 were expressed in spinal cord, medulla, pons, diencephalon, hippocampus, pituitary, cortex and cerebellum of the fetal, newborn and adult sheep brain. Expression(More)
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