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Comparative tissue distribution and excretion of [1-14C]acrylamide in beagle dogs and miniature pigs.
Male beagle dogs and miniature pigs were given acrylamide in the diet for 3-4 wk at a dosage of 1 mg/kg/day. They were then given [1-14C]acrylamide as a single oral dose of 1 mg/kg. The animals wereExpand
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Maternal-foetal distribution studies in late pregnancy. II. Distribution of [1-14C]acrylamide in tissues of beagle dogs and miniature pigs.
[carbonyl-14C]Acrylamide was administered iv as a single dose (5 mg/kg) to pregnant beagle dogs and miniature pigs late in gestation. After a 2-hr equilibration period, the animals were killed andExpand
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Distribution of 14C-labelled acrylamide and betaine in foetuses of rats, rabbits, beagle dogs and miniature pigs.
[14C]Acrylamide and [14C]betaine hydrochloride were administered in a single iv dose to pregnant rats, rabbits, beagle dogs and miniature pigs late in gestation (1-2 days before expectedExpand
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Effect of subchronic dietary administration of butylated hydroxyanisole on canine stomach and hepatic tissue.
Beagle dogs, 29 males and 30 females, were assigned to feeding groups of 0, 1.0 and 1.3% butylated hydroxyanisole (BHA) for 180 days. Animals were observed daily for physical signs of pharmacologicalExpand
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Maternal-foetal distribution studies in late pregnancy. I. Distribution of [N-methyl-14C]betaine in tissues of beagle dogs and miniature pigs.
[N-Me-14C]Betaine was administered iv as a single dose (5 mg/kg) to pregnant beagle dogs and miniature pigs late in gestation. Two hr after administration of the radiolabel, when the compound was inExpand
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Aspects of neurotoxic effects of lead in neonate Beagle dogs
Toxicological investigations were conducted in order to assess the potential value of a Beagle dog as a canine model for the study of neurotoxic effects in neonates. Forty-three daily doses of 32Expand
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A Comparison of Physiological and Biochemical Parameters in Fully Conscious Hormel-Hanford and Yucatan Strains of Miniature Pig
The Yucatan miniature pig was introduced to FDA’s Beltsville Research Facility in the early 1980s. We were impressed by the docile, calm temperament of this strain of miniature pig. The existingExpand