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The effects of a range of antidepressants were investigated on neuronal voltage-gated Na(+) and K(+) channels. With the exception of phenelzine, all antidepressants inhibited batrachotoxin-stimulated 22Na(+) uptake, most likely via negative allosteric inhibition of batrachotoxin binding to neurotoxin receptor site-2 on the Na(+) channel. Imipramine also(More)
In this paper we report for the first time the design, fabrication and characterization of an optically transparent electrode array for micro-electrocorticography. We present a 49-channel μECoG array with an electrode pitch of 800 μm and a 16-channel linear μECoG array with an electrode pitch of 200 μm. The backing material was Parylene C. Transparent,(More)
Tremor is clinically evaluated and classified on the basis of its response to limb posture (resting, postural, and kinetic tremor), but the mechanisms underlying this powerful influence remain unclear and no satisfactory method exists to identify or quantify underlying tremor subtypes. Postural change is closely linked to changes in gravitational load. We(More)
As the computation and communication circuits we build radically miniaturize (i.e. become so low power that 1 pJ is sufficient to bang out a bit of information over a wireless transceiver; become so small that 500 &mu;m<sup>2</sup> of thinned CMOS can hold a reasonable sensor front-end and digital engine), the barrier to introducing all sorts of interfaces(More)
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