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Polymerase chain reaction (PCR)-directed sequence analysis was performed to characterize the genomic and cDNA breakpoint junctions of t(11;22) (q24;q12) translocation in a case of Ewing's sarcoma, in which the EWS gene located on chromosome 22 is rearranged with the FL11 gene located on chromosome 11. RNA-PCR revealed the novel chimeric product of EWS/FL11(More)
There is substantial evidence to suggest that inherited predisposition is an important factor in the incidence of colorectal adenomas and carcinomas (reviews by Bishop & Thomas, 1990; Burt et al., 1991). The hereditary colorectal cancer syndromes which have been most fully characterised are familial adenomatous polyposis (FAP) and hereditary non-polyposis(More)
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